Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair

The DNA damage response (DDR) has an essential function in maintaining genomic stability. Ataxia telangiectasia-mutated (ATM)-checkpoint kinase 2 (Chk2) and ATM- and Rad3-related (ATR)-Chk1, triggered, respectively, by DNA double-strand breaks and blocked replication forks, are two major DDRs proces...

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Bibliographic Details
Main Authors: Chou, Wen-Cheng, Wang, Hui-Chun, Wong, Fen-Hwa, Ding, Shian-ling, Wu, Pei-Ei, Shieh, Sheau-Yann, Shen, Chen-Yang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2599873/
https://ncbi.nlm.nih.gov/pubmed/18971944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.229
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