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Small- and Large-Scale Conformational Changes of Adenylate Kinase: A Molecular Dynamics Study of the Subdomain Motion and Mechanics

Adenylate kinase, an enzyme that catalyzes the phosphoryl transfer between ATP and AMP, can interconvert between the open and catalytically potent (closed) forms even without binding ligands. Several aspects of the enzyme elasticity and internal dynamics are analyzed here by atomistic molecular dyna...

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מידע ביבליוגרפי
Main Authors: Pontiggia, Francesco, Zen, Andrea, Micheletti, Cristian
פורמט: Artigo
שפה:Inglês
יצא לאור: The Biophysical Society 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2599863/
https://ncbi.nlm.nih.gov/pubmed/18931260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.135467
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