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Energetics and Structural Characterization of the large-scale Functional Motion of Adenylate Kinase

Adenylate Kinase (AK) is a signal transducing protein that regulates cellular energy homeostasis balancing between different conformations. An alteration of its activity can lead to severe pathologies such as heart failure, cancer and neurodegenerative diseases. A comprehensive elucidation of the la...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Formoso, Elena, Limongelli, Vittorio, Parrinello, Michele
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325324/
https://ncbi.nlm.nih.gov/pubmed/25672826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08425
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