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Interconversion of Functional Motions between Mesophilic and Thermophilic Adenylate Kinases

Dynamic properties are functionally important in many proteins, including the enzyme adenylate kinase (AK), for which the open/closed transition limits the rate of catalytic turnover. Here, we compare our previously published coarse-grained (double-well Gō) simulation of mesophilic AK from E. coli (...

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Detalhes bibliográficos
Main Authors: Daily, Michael D., Phillips, George N., Cui, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136430/
https://ncbi.nlm.nih.gov/pubmed/21779157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002103
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