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Many local motions cooperate to produce the adenylate kinase conformational transition
Conformational transitions are functionally important in many proteins. In the enzyme adenylate kinase (AK), two small domains (LID and NMP) close over the larger CORE domain; the reverse (opening) motion limits the rate of catalytic turnover. Here, using double-well Gō simulations of E. coli AK, we...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902635/ https://ncbi.nlm.nih.gov/pubmed/20471396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.05.015 |
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