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Conformational Properties of Equilenin-DNA Adducts: Stereoisomer and Base Effects
Equilin and equilenin, components of the hormone replacement therapy drug Premarin, can be metabolized to the catechol 4-hydroxyequilenin (4-OHEN). The quinoids produced by 4-OHEN oxidation react with dC, dA and dG to form unusual stable cyclic adducts, which have been found in human breast tumor ti...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597795/ https://ncbi.nlm.nih.gov/pubmed/18416538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800010u |
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