Phosphatase-Resistant Analogues of Lysophosphatidic Acid: Agonists Promote Healing, Antagonists and Autotaxin Inhibitors Treat Cancer

Isoform-selective agonists and antagonists of the lysophosphatidic acid (LPA) G protein coupled receptors (GPCRs) have important potential applications in cell biology and therapy. LPA GPCRs regulate cancer cell proliferation, invasion, angiogenesis, and also biochemical resistance to chemotherapy-...

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Bibliographic Details
Main Authors: Prestwich, Glenn D., Gajewiak, Joanna, Zhang, Honglu, Xu, Xiaoyu, Yang, Guanghui, Serban, Monica
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597578/
https://ncbi.nlm.nih.gov/pubmed/18454946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2008.03.008
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