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Inhibition of Tumor Growth and Angiogenesis by a Lysophosphatidic Acid Antagonist in a Engineered Three-dimensional Lung Cancer Xenograft Model
BACKGROUND: We developed an engineered three-dimensional (3-D) tumor xenograft model of non-small cell lung cancer (NSCLC) in nude mice, and used this model to evaluate a dual-activity inhibitor of lysophosphatidic acid (LPA) biosynthesis and receptor activation. METHODS: First, BrP-LPA, a pan-antag...
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| Main Authors: | , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2010
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847044/ https://ncbi.nlm.nih.gov/pubmed/20143443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.24907 |
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