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Use of Docking Peptides to Design Modular Substrates with High Efficiency for MAP Kinase ERK
The mitogen-activated protein (MAP) kinase ERK plays a key role in the regulation of cellular proliferation. Mutations in the ERK cascade occur in 30% of malignant tumors. Thus understanding how the kinase identifies its cognate substrates as well as monitoring the activity of ERK is central to canc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597387/ https://ncbi.nlm.nih.gov/pubmed/17918909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb700158q |
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