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The IL-15 receptor α chain cytoplasmic domain is critical for normal IL-15Rα function but is not required for trans-presentation
IL-15 is critical for natural killer (NK)–cell development and function and for memory CD8(+) T-cell homeostasis. The IL-15 receptor consists of IL-15Rα, IL-2Rβ, and the common cytokine receptor γ chain (γ(c)). IL-15Rα is known to “trans-present” IL-15 to an IL-2Rβ/γ(c) heterodimeric receptor on res...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2008
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597117/ https://ncbi.nlm.nih.gov/pubmed/18796634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-080697 |
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