The IL-15 receptor α chain cytoplasmic domain is critical for normal IL-15Rα function but is not required for trans-presentation

IL-15 is critical for natural killer (NK)–cell development and function and for memory CD8(+) T-cell homeostasis. The IL-15 receptor consists of IL-15Rα, IL-2Rβ, and the common cytokine receptor γ chain (γ(c)). IL-15Rα is known to “trans-present” IL-15 to an IL-2Rβ/γ(c) heterodimeric receptor on res...

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Bibliographic Details
Main Authors: Wu, Zheng, Xue, Hai-Hui, Bernard, Jérôme, Zeng, Rong, Issakov, Dmitry, Bollenbacher-Reilley, Julie, Belyakov, Igor M., Oh, SangKon, Berzofsky, Jay A., Leonard, Warren J.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Chemokines, Cytokines, and Interleukins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597117/
https://ncbi.nlm.nih.gov/pubmed/18796634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-080697
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