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Design, Synthesis and Biological Evaluation of β-Ketosulfonamide Adenylation Inhibitors as Potential Antitubercular Agents
[Image: see text] The antitubercular nucleoside antibiotics 1 and 2 were recently described that inhibit the adenylate-forming enzyme MbtA and disrupt biosynthesis of the virulence-conferring siderophore known as mycobactin in M. tuberculosis. Herein, we report efforts to refine this inhibitor scaff...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596716/ https://ncbi.nlm.nih.gov/pubmed/17020283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol0617289 |
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