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Design, Synthesis and Biological Evaluation of β-Ketosulfonamide Adenylation Inhibitors as Potential Antitubercular Agents

[Image: see text] The antitubercular nucleoside antibiotics 1 and 2 were recently described that inhibit the adenylate-forming enzyme MbtA and disrupt biosynthesis of the virulence-conferring siderophore known as mycobactin in M. tuberculosis. Herein, we report efforts to refine this inhibitor scaff...

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Bibliografiske detaljer
Main Authors: Vannada, Jagadeshwar, Bennett, Eric M., Wilson, Daniel, Boshoff, Helena I., Barry, Clifton E., Aldrich, Courtney C.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596716/
https://ncbi.nlm.nih.gov/pubmed/17020283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol0617289
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