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Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16(Ink4a) and Arf
Lymphoid progenitors exhibit severe growth defects during aging while myelopoiesis is relatively unperturbed. These effects are due in part to the preferential expression of p16(Ink4a) and Arf in aged lymphoid progenitors. Their increased expression contributes to reduced growth and survival of lymp...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593609/ https://ncbi.nlm.nih.gov/pubmed/19056891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1715808 |
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