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Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph(+) B-acute lymphoblastic leukemia

Philadelphia chromosome–positive (Ph(+)) B-acute lymphoblastic leukemia (B-ALL) can initiate in committed B-cell progenitors. However, the stages of B-cell differentiation in which disease can initiate and the efficiency with which this occurs are unclear. We now demonstrate that B-cell progenitors,...

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Detalhes bibliográficos
Main Authors: Signer, Robert A. J., Montecino-Rodriguez, Encarnacion, Witte, Owen N., Dorshkind, Kenneth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953887/
https://ncbi.nlm.nih.gov/pubmed/20562326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-264093
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