Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif

Tissue development and function are exquisitely dependent on proper regulation of gene expression, but it remains controversial whether the genomic signals controlling this process are subject to strong selective constraint. While some studies show that highly constrained noncoding regions act to en...

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Bibliografske podrobnosti
Main Authors: Cheng, Yong, King, David C., Dore, Louis C., Zhang, Xinmin, Zhou, Yuepin, Zhang, Ying, Dorman, Christine, Abebe, Demesew, Kumar, Swathi A., Chiaromonte, Francesca, Miller, Webb, Green, Roland D., Weiss, Mitchell J., Hardison, Ross C.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2008
Teme:
Letter
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593580/
https://ncbi.nlm.nih.gov/pubmed/18818370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.083089.108
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