Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif

Tissue development and function are exquisitely dependent on proper regulation of gene expression, but it remains controversial whether the genomic signals controlling this process are subject to strong selective constraint. While some studies show that highly constrained noncoding regions act to en...

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Detalhes bibliográficos
Main Authors: Cheng, Yong, King, David C., Dore, Louis C., Zhang, Xinmin, Zhou, Yuepin, Zhang, Ying, Dorman, Christine, Abebe, Demesew, Kumar, Swathi A., Chiaromonte, Francesca, Miller, Webb, Green, Roland D., Weiss, Mitchell J., Hardison, Ross C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Letter
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593580/
https://ncbi.nlm.nih.gov/pubmed/18818370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.083089.108
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