Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload

We tested the possibility that proteasome inhibition may reverse preexisting cardiac hypertrophy and improve remodeling upon pressure overload. Mice were submitted to aortic banding and followed up for 3 wk. The proteasome inhibitor epoxomicin (0.5 mg/kg) or the vehicle was injected daily, starting...

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Detalhes bibliográficos
Main Authors: Hedhli, Nadia, Lizano, Paulo, Hong, Chull, Fritzky, Luke F., Dhar, Sunil K., Liu, Huasheng, Tian, Yimin, Gao, Shumin, Madura, Kiran, Vatner, Stephen F., Depre, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593511/
https://ncbi.nlm.nih.gov/pubmed/18676687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00532.2008
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