Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload

We tested the possibility that proteasome inhibition may reverse preexisting cardiac hypertrophy and improve remodeling upon pressure overload. Mice were submitted to aortic banding and followed up for 3 wk. The proteasome inhibitor epoxomicin (0.5 mg/kg) or the vehicle was injected daily, starting...

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Bibliografiske detaljer
Main Authors: Hedhli, Nadia, Lizano, Paulo, Hong, Chull, Fritzky, Luke F., Dhar, Sunil K., Liu, Huasheng, Tian, Yimin, Gao, Shumin, Madura, Kiran, Vatner, Stephen F., Depre, Christophe
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593511/
https://ncbi.nlm.nih.gov/pubmed/18676687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00532.2008
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