H11 kinase/heat shock protein 22 deletion impairs both nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure on cardiac overload

BACKGROUND: Cardiac overload, a major cause of heart failure, induces the expression of the heat shock protein H11 kinase/Hsp22 (Hsp22). METHODS AND RESULTS: To determine the specific function of Hsp22 in that context, a knockout (KO) mouse model of Hsp22 deletion was generated. Although comparable...

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Главные авторы: Qiu, Hongyu, Lizano, Paulo, Laure, Lydie, Sui, Xiangzhen, Rashed, Eman, Park, Ji Yeon, Hong, Chull, Gao, Shumin, Holle, Eric, Morin, Didier, Dhar, Sunil K., Wagner, Thomas E., Berdeaux, Alain, Tian, Bin, Vatner, Stephen F., Depre, Christophe
Формат: Artigo
Язык:Inglês
Опубликовано: Lippincott Williams & Wilkins 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369833/
https://ncbi.nlm.nih.gov/pubmed/21747053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.013847
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