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Effects of L-Lactate and D-Mannitol on γ-Hydroxybutyrate Toxicokinetics and Toxicodynamics in Rats

Overdoses of γ-hydroxybutyrate (GHB), a drug of abuse, result in coma, respiratory arrest, and death. The objective of this study was to evaluate a potential GHB detoxification strategy by inhibiting the monocarboxylate transporter (MCT)-mediated renal reabsorption of GHB in rats, using the MCT subs...

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Detalhes bibliográficos
Main Authors: Wang, Qi, Wang, Xiaodong, Morris, Marilyn E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593404/
https://ncbi.nlm.nih.gov/pubmed/18719239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.022996
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