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Toxicokinetic/Toxicodynamic Interaction Studies in Rats between the Drugs of Abuse γ-Hydroxybutyric Acid and Ketamine and Treatment Strategies for Overdose

γ-hydroxybutyric acid (GHB) is widely abused alone and in combination with other club drugs such as ketamine. GHB exhibits nonlinear toxicokinetics, characterized by saturable metabolism, saturable absorption and saturable renal reabsorption mediated by monocarboxylate transporters (MCTs). In this r...

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Bibliografski detalji
Izdano u:Pharmaceutics
Glavni autori: Kwatra, Nisha V., Morris, Marilyn E.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157280/
https://ncbi.nlm.nih.gov/pubmed/34069815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13050741
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