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Mechanistic Modeling of Monocarboxylate Transporter-Mediated Toxicokinetic/Toxicodynamic Interactions Between γ-Hydroxybutyrate and l-Lactate

Overdose of γ-hydroxybutyrate (GHB) can result in severe respiratory depression. Monocarboxylate transporter (MCT) inhibitors, including l-lactate, increase GHB clearance and represent a potential treatment for GHB intoxication. GHB can also affect l-lactate clearance, and l-lactate has been reporte...

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Bibliographic Details
Main Authors: Morse, Bridget L., Vijay, Nisha, Morris, Marilyn E.
Format: Artigo
Language:Inglês
Published: Springer US 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070269/
https://ncbi.nlm.nih.gov/pubmed/24854892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9593-8
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