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Pharmacokinetic Interaction between the Flavonoid Luteolin and γ-Hydroxybutyrate in Rats: Potential Involvement of Monocarboxylate Transporters

Monocarboxylate transporter 1 (MCT1) has been previously reported as an important determinant of the renal reabsorption of the drug of abuse, γ-hydroxybutyrate (GHB). Luteolin is a potent MCT1 inhibitor, inhibiting the uptake of GHB with an IC(50) of 0.41 μM in MCT1-transfected MDA-MB231 cells. The...

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Detalhes bibliográficos
Main Authors: Wang, Xiaodong, Wang, Qi, Morris, Marilyn E.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751446/
https://ncbi.nlm.nih.gov/pubmed/18446505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-007-9001-8
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