Minimal Effects of Ritonavir and Efavirenz on the Pharmacokinetics of Raltegravir

Raltegravir is a novel human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor with potent in vitro activity against HIV-1 (95% inhibitory concentration = 31 nM in 50% human serum). The possible effects of ritonavir and efavirenz on raltegravir pharmacokinetics were separatel...

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Hauptverfasser: Iwamoto, Marian, Wenning, Larissa A., Petry, Amelia S., Laethem, Martine, De Smet, Marina, Kost, James T., Breidinger, Sheila A., Mangin, Eric C., Azrolan, Neal, Greenberg, Howard E., Haazen, Wouter, Stone, Julie A., Gottesdiener, Keith M., Wagner, John A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592871/
https://ncbi.nlm.nih.gov/pubmed/18838589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01543-07
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