In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning

Infusion of transduced hematopoietic stem cells into nonmyeloablated hosts results in ineffective in vivo levels of transduced cells. To increase the proportion of transduced cells in vivo, selection based on P140K O(6)-methylguanine-DNA-methyltransferase (MGMT[P140K]) gene transduction and O(6)-ben...

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Detalhes bibliográficos
Main Authors: Zielske, Steven P., Reese, Jane S., Lingas, Karen T., Donze, Jon R., Gerson, Stanton L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC259124/
https://ncbi.nlm.nih.gov/pubmed/14617757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317922
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