Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection

Foamy virus (FV) vectors are promising for hematopoietic stem cell (HSC) gene therapy but preclinical data on the clonal composition of FV vector transduced human repopulating cells is needed. Human CD34(+) human cord blood cells were transduced with an FV vector encoding a methylguanine methyltrans...

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Bibliographische Detailangaben
Veröffentlicht in:Gene Ther
Hauptverfasser: Olszko, Miles E., Adair, Jennifer E., Linde, Ian, Rae, Dustin T., Trobridge, Patty, Hocum, Jonah D., Rawlings, David J., Kiem, Hans-Peter, Trobridge, Grant D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490015/
https://ncbi.nlm.nih.gov/pubmed/25786870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2015.20
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