Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection

Foamy virus (FV) vectors are promising for hematopoietic stem cell (HSC) gene therapy but preclinical data on the clonal composition of FV vector transduced human repopulating cells is needed. Human CD34(+) human cord blood cells were transduced with an FV vector encoding a methylguanine methyltrans...

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Bibliografske podrobnosti
izdano v:Gene Ther
Main Authors: Olszko, Miles E., Adair, Jennifer E., Linde, Ian, Rae, Dustin T., Trobridge, Patty, Hocum, Jonah D., Rawlings, David J., Kiem, Hans-Peter, Trobridge, Grant D.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490015/
https://ncbi.nlm.nih.gov/pubmed/25786870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2015.20
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