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In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning
Infusion of transduced hematopoietic stem cells into nonmyeloablated hosts results in ineffective in vivo levels of transduced cells. To increase the proportion of transduced cells in vivo, selection based on P140K O(6)-methylguanine-DNA-methyltransferase (MGMT[P140K]) gene transduction and O(6)-ben...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC259124/ https://ncbi.nlm.nih.gov/pubmed/14617757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317922 |
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