In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning

Infusion of transduced hematopoietic stem cells into nonmyeloablated hosts results in ineffective in vivo levels of transduced cells. To increase the proportion of transduced cells in vivo, selection based on P140K O(6)-methylguanine-DNA-methyltransferase (MGMT[P140K]) gene transduction and O(6)-ben...

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Autores principales: Zielske, Steven P., Reese, Jane S., Lingas, Karen T., Donze, Jon R., Gerson, Stanton L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2003
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC259124/
https://ncbi.nlm.nih.gov/pubmed/14617757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317922
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