In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning

Infusion of transduced hematopoietic stem cells into nonmyeloablated hosts results in ineffective in vivo levels of transduced cells. To increase the proportion of transduced cells in vivo, selection based on P140K O(6)-methylguanine-DNA-methyltransferase (MGMT[P140K]) gene transduction and O(6)-ben...

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Udgivet i:J Clin Invest
Main Authors: Zielske, Steven P., Reese, Jane S., Lingas, Karen T., Donze, Jon R., Gerson, Stanton L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
Fag:
Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC259124/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14617757/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI17922
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