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Metabolism of melatonin by cytochrome P-450s in rat liver mitochondria and microsomes
In the present study we provide direct evidence for the involvement of rat microsomal cytochrome P450s in melatonin O-demethylation and hydroxylation at two different positions: 2 and 6, as well as generation of N(1)-acetyl-N(2)-formyl-5-methoxy-kynuramine (AFMK) and two unknown products. Moreover,...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587488/ https://ncbi.nlm.nih.gov/pubmed/18717775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-079X.2008.00630.x |
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