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The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism

We show that cytochrome P450scc (CYP11A1) in either a reconstituted system or in isolated adrenal mitochondria can metabolize vitamin D3. The major products of the reaction with reconstituted enzyme were 20-hydroxycholecalciferol and 20,22-dihydroxycholecalciferol, with yields of 16 and 4%, respecti...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Slominski, Andrzej, Semak, Igor, Zjawiony, Jordan, Wortsman, Jacobo, Li, Wei, Szczesniewski, Andre, Tuckey, Robert C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2005
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234577/
https://ncbi.nlm.nih.gov/pubmed/16098191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2005.04819.x
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