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A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin

Following up on our previous findings that the skin possesses steroidogenic activity from progesterone, we now show widespread cutaneous expression of the full cytochrome P450 side-chain cleavage (P450scc) system required for the intracellular catalytic production of pregnenolone, i.e. the genes and...

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Detalhes bibliográficos
Main Authors: Slominski, Andrzej, Zjawiony, Jordan, Wortsman, Jacobo, Semak, Igor, Stewart, Jeremy, Pisarchik, Alexander, Sweatman, Trevor, Marcos, Josep, Dunbar, Chuck, Tuckey, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201497/
https://ncbi.nlm.nih.gov/pubmed/15511223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1432-1033.2004.04356.x
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