An alternative pathway of vitamin D(2) metabolism Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D(2) and 17,20-dihydroxyvitamin D(2)

We report an alternative, hydroxylating pathway for the metabolism of vitamin D(2) in a cytochrome P450 side chain cleavage (P450scc; CYP11A1) reconstituted system. NMR analyses identified solely 20-hydroxyvitamin D(2) and 17,20-dihydroxyvitamin D(2) derivatives. 20-Hydroxyvitamin D(2) was produced...

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Detalhes bibliográficos
Main Authors: Slominski, Andrzej, Semak, Igor, Wortsman, Jacobo, Zjawiony, Jordan, Li, Wei, Zbytek, Blazej, Tuckey, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1893115/
https://ncbi.nlm.nih.gov/pubmed/16817851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2006.05302.x
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