Activating mutations in ALK provide a therapeutic target in neuroblastoma

Neuroblastoma, an embryonal tumor of the peripheral sympathetic nervous system, accounts for approximately 15% of all deaths due to childhood cancer1. High-risk neuroblastomas, prevalent in the majority of patients, are rapidly progressive; even with intensive myeloablative chemotherapy, relapse is...

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Detalhes bibliográficos
Main Authors: George, Rani E., Sanda, Takaomi, Hanna, Megan, Fröhling, Stefan, Luther, William, Zhang, Jianming, Ahn, Yebin, Zhou, Wenjun, London, Wendy B., McGrady, Patrick, Xue, Liquan, Zozulya, Sergey, Gregor, Vlad, Webb, Thomas R., Gray, Nathanael S., Gilliland, D. Gary, Diller, Lisa, Greulich, Heidi, Morris, Stephan W., Meyerson, Matthew, Look, A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587486/
https://ncbi.nlm.nih.gov/pubmed/18923525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07397
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