Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis

Amplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by mutational activation of ALK (anaplastic lymphoma kinase), suggesting their pathogenic cooperation. We generated a transgenic zebrafish model of neuroblastoma in which MYCN-induced tumors arise from a subpopulation...

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Hauptverfasser: Zhu, Shizhen, Lee, Jeong-Soo, Guo, Feng, Shin, Jimann, Perez-Atayde, Antonio R., Kutok, Jeffery L., Rodig, Scott J., Neuberg, Donna S., Helman, Daniel, Feng, Hui, Stewart, Rodney A., Wang, Wenchao, George, Rani E., Kanki, John P., Look, A. Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315700/
https://ncbi.nlm.nih.gov/pubmed/22439933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.02.010
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