Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis

Amplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by mutational activation of ALK (anaplastic lymphoma kinase), suggesting their pathogenic cooperation. We generated a transgenic zebrafish model of neuroblastoma in which MYCN-induced tumors arise from a subpopulation...

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Detalhes bibliográficos
Main Authors: Zhu, Shizhen, Lee, Jeong-Soo, Guo, Feng, Shin, Jimann, Perez-Atayde, Antonio R., Kutok, Jeffery L., Rodig, Scott J., Neuberg, Donna S., Helman, Daniel, Feng, Hui, Stewart, Rodney A., Wang, Wenchao, George, Rani E., Kanki, John P., Look, A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315700/
https://ncbi.nlm.nih.gov/pubmed/22439933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.02.010
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