Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis

Amplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by mutational activation of ALK (anaplastic lymphoma kinase), suggesting their pathogenic cooperation. We generated a transgenic zebrafish model of neuroblastoma in which MYCN-induced tumors arise from a subpopulation...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhu, Shizhen, Lee, Jeong-Soo, Guo, Feng, Shin, Jimann, Perez-Atayde, Antonio R., Kutok, Jeffery L., Rodig, Scott J., Neuberg, Donna S., Helman, Daniel, Feng, Hui, Stewart, Rodney A., Wang, Wenchao, George, Rani E., Kanki, John P., Look, A. Thomas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315700/
https://ncbi.nlm.nih.gov/pubmed/22439933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.02.010
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