Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice

We examined the effects of ibuprofen on cognitive deficits, Aβ and tau accumulation in young triple transgenic (3×Tg-AD) mice. 3×Tg-AD mice were fed ibuprofen-supplemented chow between 1 and 6 months. Untreated 3×Tg-AD mice showed significant impairment in the ability to learn the Morris water maze...

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Detalhes bibliográficos
Main Authors: McKee, Ann C., Carreras, Isabel, Hossain, Lokman, Ryu, Hoon, Klein, William L., Oddo, Salvatore, LaFerla, Frank M., Jenkins, Bruce G., Kowall, Neil W., Dedeoglu, Alpaslan
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587244/
https://ncbi.nlm.nih.gov/pubmed/18374906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2008.01.095
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