Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, SLE-like autoimmunity

In otherwise non-autoimmune-prone C57BL/6 (B6) mice rendered genetically deficient in CD152 (CTLA-4), polyclonal hypergammaglobulinemia with increased levels of SLE-associated IgG autoantibodies, glomerular IgG and C3 deposition, and interstitial nephritis all developed by 3-5 weeks of age. Remarkab...

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Hauptverfasser: Stohl, William, Jacob, Noam, Quinn, William J., Cancro, Michael P., Gao, Huaxin, Putterman, Chaim, Gao, Xiaoni, Pricop, Luminita, Koss, Michael N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587218/
https://ncbi.nlm.nih.gov/pubmed/18566449
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