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Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, SLE-like autoimmunity

In otherwise non-autoimmune-prone C57BL/6 (B6) mice rendered genetically deficient in CD152 (CTLA-4), polyclonal hypergammaglobulinemia with increased levels of SLE-associated IgG autoantibodies, glomerular IgG and C3 deposition, and interstitial nephritis all developed by 3-5 weeks of age. Remarkab...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Stohl, William, Jacob, Noam, Quinn, William J., Cancro, Michael P., Gao, Huaxin, Putterman, Chaim, Gao, Xiaoni, Pricop, Luminita, Koss, Michael N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587218/
https://ncbi.nlm.nih.gov/pubmed/18566449
Tagiau: Ychwanegu Tag
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