An anti-TGF-β antibody suppresses metastasis via cooperative effects on multiple cell compartments

Overexpression of transforming growth factor β (TGF-β) is frequently associated with metastasis and poor prognosis, and TGF-β antagonism has been shown to prevent metastasis in preclinical models with surprisingly little toxicity. Here we have used the transplantable 4T1 model of metastatic breast c...

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Hlavní autoři: Nam, Jeong-Seok, Terabe, Masaki, Mamura, Mizuko, Kang, Mi-Jin, Chae, Helen, Stuelten, Christina, Kohn, Ethan, Tang, Binwu, Sabzevari, Helen, Anver, Miriam R., Lawrence, Scott, Danielpour, David, Lonning, Scott, Berzofsky, Jay, Wakefield, Lalage M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587151/
https://ncbi.nlm.nih.gov/pubmed/18483268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0215
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