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Blockade of TGF-β enhances tumor vaccine efficacy mediated by CD8(+) T cells

Though TGF-β inhibition enhances anti-tumor immunity mediated by CD8(+) T cells in several tumor models, it is not always sufficient for rejection of tumors. In the present study, to maximize the anti-tumor effect of TGF-β blockade, we tested the effect of anti-TGF-β combined with an irradiated tumo...

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Detalhes bibliográficos
Main Authors: Takaku, Shun, Terabe, Masaki, Ambrosino, Elena, Peng, Judy, Lonning, Scott, McPherson, John M., Berzofsky, Jay A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818422/
https://ncbi.nlm.nih.gov/pubmed/19830696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24961
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