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Synergistic enhancement of CD8(+) T cell-mediated tumor vaccine efficacy by an anti-TGF-β monoclonal antibody
PURPOSE: TGF-β is an immunosuppressive cytokine, having direct suppressive activity against conventional CD4(+) and CD8(+)T cells and NK cells, thereby inhibiting tumor immunosurveillance. Here we investigated possible synergy between anti-TGF-β (1D11) and a peptide vaccine on induction of anti-tumo...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804258/ https://ncbi.nlm.nih.gov/pubmed/19861451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1066 |
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