TGF-β can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model

The TGF-β pathway has tumor suppressor activity in many epithelial tissues. Since TGF-β is a potent inhibitor of epithelial cell proliferation, it has been widely assumed that this property underlies the tumor suppressor effect. Here we have used a xenograft model of breast cancer to show that endog...

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Detalhes bibliográficos
Main Authors: Tang, Binwu, Yoo, Naomi, Vu, Mary, Mamura, Mizuko, Nam, Jeong-Seok, Ooshima, Akira, Du, Zhijun, Desprez, Pierre-Yves, Anver, Miriam R., Michalowska, Aleksandra M., Shih, Joanna, Parks, W. Tony, Wakefield, Lalage M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427144/
https://ncbi.nlm.nih.gov/pubmed/17875704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-0982
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