An anti-TGF-β antibody suppresses metastasis via cooperative effects on multiple cell compartments

Overexpression of transforming growth factor β (TGF-β) is frequently associated with metastasis and poor prognosis, and TGF-β antagonism has been shown to prevent metastasis in preclinical models with surprisingly little toxicity. Here we have used the transplantable 4T1 model of metastatic breast c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nam, Jeong-Seok, Terabe, Masaki, Mamura, Mizuko, Kang, Mi-Jin, Chae, Helen, Stuelten, Christina, Kohn, Ethan, Tang, Binwu, Sabzevari, Helen, Anver, Miriam R., Lawrence, Scott, Danielpour, David, Lonning, Scott, Berzofsky, Jay, Wakefield, Lalage M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587151/
https://ncbi.nlm.nih.gov/pubmed/18483268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0215
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