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Linking SNP identity to CAG repeat length in Huntington’s Disease patients
Allele-specific silencing using siRNAs targeting heterozygous single-nucleotide polymorphisms (SNPs) is a promising therapy for trinucleotide repeat diseases, such as Huntington’s disease (HD). Linking SNP identities to the two huntingtin (HTT) alleles—normal and disease-causing—is a prerequisite fo...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587014/ https://ncbi.nlm.nih.gov/pubmed/18931668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1261 |
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