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Recognition of the activated states of Gα13 by the rgRGS domain of PDZRhoGEF
G12 class heterotrimeric G proteins stimulate RhoA activation by RGS-RhoGEFs. However, p115RhoGEF is a GTPase Activating Protein (GAP) towards Gα13 while PDZRhoGEF is not. We have characterized interaction between the PDZRhoGEF rgRGS domain (PRG-rgRGS) and the alpha subunit of G13, and determined cr...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2586972/ https://ncbi.nlm.nih.gov/pubmed/18940608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.07.009 |
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