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Hydromorphone efficacy and treatment protocol impact on tolerance and μ-opioid receptor regulation
This study examined the antinociceptive (analgesic) efficacy of hydromorphone and hydromorphone-induced tolerance and regulation of μ-opioid receptor density. Initially s.c. hydromorphone’s time of peak analgesic (tail-flick) effect (45 min) and ED(50) using standard and cumulative dosing protocols...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2586831/ https://ncbi.nlm.nih.gov/pubmed/18789923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2008.08.025 |
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