The Relative Potency of Inverse Opioid Agonists and a Neutral Opioid Antagonist in Precipitated Withdrawal and Antagonism of Analgesia and Toxicity

Opioid antagonists can be classified as inverse agonists and neutral antagonists. In the opioid-dependent state, neutral antagonists are significantly less potent in precipitating withdrawal than inverse agonists. Consequently, neutral opioid antagonists may offer advantages over inverse agonists in...

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Autores principales: Sirohi, Sunil, Dighe, Shveta V., Madia, Priyanka A., Yoburn, Byron C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Pharmacology and Experimental Therapeutics 2009
Materias:
Neuropharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713087/
https://ncbi.nlm.nih.gov/pubmed/19435929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.152678
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