The Analgesic Efficacy of Fentanyl: Relationship to Tolerance and μ-Opioid Receptor Regulation

This study determined if fentanyl analgesic efficacy predicts the magnitude of tolerance and μ-opioid receptor regulation. To estimate efficacy, mice were injected i.p. with saline or clocinnamox (CCAM), an irreversible μ-opioid receptor antagonist, (0.32 – 25.6 mg/kg) and 24 hr later fentanyl cumul...

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Main Authors: Sirohi, Sunil, Dighe, Shveta V., Walker, Ellen A., Yoburn, Byron C.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597555/
https://ncbi.nlm.nih.gov/pubmed/18640146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2008.06.019
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