TGF-β subverts the immune system into directly promoting tumor growth through IL-17

Overexpression of the immunosuppressive cytokine TGF-β is one strategy that tumors have evolved to evade effective immunesurveillance. Using transplantable models of breast and colon cancer, we made the unexpected finding that CD8+ cells in tumor-bearing animals can directly promote tumorigenesis, b...

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Bibliografiske detaljer
Main Authors: Nam, Jeong-Seok, Terabe, Masaki, Kang, Mi-Jin, Chae, Helen, Voong, Nga, Yang, Yu-an, Laurence, Arian, Michalowska, Aleksandra, Mamura, Mizuko, Lonning, Scott, Berzofsky, Jay A., Wakefield, Lalage M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586596/
https://ncbi.nlm.nih.gov/pubmed/18483277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0206
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