Low pH-induced changes in Pseudomonas exotoxin and its domains: increased binding of Triton X-114.

Pseudomonas exotoxin (PE), which is composed of three structural domains, is a 66-kilodalton protein secreted by P. aeruginosa that is cytotoxic for mammalian cells. After binding to cell surface receptors and internalization into low-pH endocytic vesicles, PE or an active fragment kills mammalian c...

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Bibliografiske detaljer
Udgivet i:Infect Immun
Main Authors: Idziorek, T, FitzGerald, D, Pastan, I
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258641/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2108931/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.5.1415-1420.1990
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